Phenolic aporphine-benzylisoquinoline alkaloids from Thalictrum faberi
Identifieur interne : 002604 ( Main/Exploration ); précédent : 002603; suivant : 002605Phenolic aporphine-benzylisoquinoline alkaloids from Thalictrum faberi
Auteurs : Long-Ze Lin [États-Unis] ; Shu-Fang Hu [États-Unis] ; Min Chu [États-Unis] ; Tze-Ming Chan [États-Unis] ; Heebyung Chai [États-Unis] ; Cindy K. Angerhofer [États-Unis] ; John M. Pezzuto [États-Unis] ; Geoffrey A. Cordell [États-Unis]Source :
- Phytochemistry [ 0031-9422 ] ; 1999.
English descriptors
- Teeft :
- Alkaloid, American chemical society, Antimalarial, Base peak, Chemical shift values, Cosy, Desmethylthalifaboramine, Faberi, Guinaudeau, Hmbc, Hmbc correlations, Hmbc spectrum, Hrms, Hussain, Leboeuf, Major results, Mass spectra, Meoh, Methoxy, Methoxy function, Methoxy functions, Methoxy groups, Methoxy signal, Natural products, Phenolic, Phenolic alkaloid, Phenolic alkaloids, Phenolic function, Phenolic functions, Phytochemistry, Roesy, Roesy spectrum, Seligman, Signal multiplicity, Thalictrum, Thalictrum faberi, Yellow powder.
Abstract
Abstract: From the roots of Thalictrum faberi, six new phenolic aporphine-benzylisoquinoline alkaloids, 3-hydroxy-6′-desmethyl-9-O-methylthalifaboramine (1), 3-hydroxythalifaboramine (2), 6′-desmethylthalifaboramine (3); 3,5′-dihydroxythalifaboramine (4), 5′-hydroxythalifaboramine (5) and 3-hydroxy-6′-desmethylthalifaboramine (6) were isolated. Their structures were established through the use of one- and two-dimensional NMR techniques. All of the tested alkaloids showed potent cytotoxic and antimalarial activities.
Url:
DOI: 10.1016/S0031-9422(98)00580-9
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Abstract: From the roots of Thalictrum faberi, six new phenolic aporphine-benzylisoquinoline alkaloids, 3-hydroxy-6′-desmethyl-9-O-methylthalifaboramine (1), 3-hydroxythalifaboramine (2), 6′-desmethylthalifaboramine (3); 3,5′-dihydroxythalifaboramine (4), 5′-hydroxythalifaboramine (5) and 3-hydroxy-6′-desmethylthalifaboramine (6) were isolated. Their structures were established through the use of one- and two-dimensional NMR techniques. All of the tested alkaloids showed potent cytotoxic and antimalarial activities.</div>
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